Interactions with Fibroblasts are Distinct in Basal-like and Luminal Breast Cancers

ABSTRACT: Basal-like breast cancers have several well-characterized distinguishing molecular features, but most of these are features of the cancer cells themselves. The unique stromal-epithelial interactions, and more generally, microenvironmental features of basal-like breast cancers, have not been well characterized. To identify characteristic microenvironment features of basal-like breast cancer, we performed cocultures of several basal-like breast cancer cell lines with fibroblasts (reduction mammoplasty-derived fibroblast line; RMF) and compared these to cocultures of luminal breast cancer cell lines with fibroblasts. Interactions between basal-like cancer cells and fibroblasts induced expression of numerous interleukins and chemokines, including IL-6, IL-8, CXCL1, CXCL3, and TGFbeta. Under th

ORGANISM(S): Homo sapiens

SUBMITTER: Troester Melissa 

PROVIDER: S-ECPF-GEOD-26411 | biostudies-other |

REPOSITORIES: biostudies-other