Differentially expressed genes in window trials are influenced by the wound healing process: lessons learned from a pilot study with Anastrozole

ABSTRACT: Introduction: Peri-operative window trials, using molecular biomarkers as surrogate endpoints for treatment response, offer investigators a uniqueopportunity to obtain intact tumor samples at 2 different time-points and thus evaluate potential biomarkers over a short period of time. Here we report results of a pilot trial designed to determine if treatment-mediated changes in gene expression can be detected after a 10-day exposure to anastrozole in estrogen receptor (ER)-positive breast cancer compared to untreated controls. Methods: Paired tumor samples (biopsy and surgical) were obtained from 26 postmenopausal women with ER-positive breast cancer. Patients were assigned anastrozole (1mg/dy) for 10 days immediately prior to surgery (13 cases) or no treatment (13 controls). 502 cancer-rela

ORGANISM(S): Homo sapiens

SUBMITTER: Andrade Victor 

PROVIDER: S-ECPF-GEOD-26544 | biostudies-other |

REPOSITORIES: biostudies-other