MicroRNA and cancer progression in breast tumors

ABSTRACT: miRNAs are small non-coding RNAs frequently altered in human malignancies. They regulate protein-coding gene expression by mediating mRNA degradation and/or repressing translation via the association with the 3’ untranslated region (3’ UTR) of the mRNAs. Aberrant miRNA expression can influence several gene networks and pathways implicated in tumorigenesis and metastasis formation. To reveal miRNAs involved in breast cancer progression we investigated miRNA expression in 77 ductal breast carcinoma biopsies and 17 mammoplasties by microarray analysis. 16 differentially expressed miRNAs were identified comparing patients with or without disease relapse within 72 months from surgery. We have performed a microarray miRNA expression analysis on 77 ductal breast carcinoma biopsies and 17 normal

ORGANISM(S): Homo sapiens

SUBMITTER: Cimino D 

PROVIDER: S-ECPF-GEOD-26659 | biostudies-other | 2013 Mar

REPOSITORIES: biostudies-other