NDRG2 transcriptional inactivation is involved in tumoral progression and worse clinical outcome of oligodendroglial tumors

ABSTRACT: Purpose: The most clearly established genetic hallmark in oligodendroglial tumors (OTs) is the combined loss of 1p/19q, a molecular alteration characteristic of tumors responding to therapy. Markers of tumoral progression have not yet been studied. Experimental Design: Novel markers of tumoral progression in OTs were sought through gene expression profiling analysis. Results: Unsupervised hierarchical cluster analysis classified OTs into two main groups associated with tumoral grade, independent of histological subtype and 1p/19q status. Differential gene expression analysis between low- and high-grade OTs revealed that only cell cycle-related genes were significantly upregulated in high-grade OTs. Among the deregulated genes, NDRG2 downregulation was detected in high-grade OTs with combi

ORGANISM(S): Homo sapiens

SUBMITTER: Melendez Barbara 

PROVIDER: S-ECPF-GEOD-27005 | biostudies-other |

REPOSITORIES: biostudies-other