Fibroblast triggered gene expression in tumor

ABSTRACT: Personalized biological insights into heterogeneous tumors, such as breast cancer could improve clinical management. While genomic analysis has contributed significantly towards dissecting breast cancer heterogeneity, limitations in clinical application are partly rooted in the inter-tumor variability arising from a largely uncharacterized interactive exchange between diverse cell types in the tumor microenvironment. Here we first identified a common response signature to stromal coculture across breast cancer of varying clinicopathologic phenotypes. Proximity to fibroblasts resulted in gene transcript alterations of >2-fold for 107 probe sets, collectively designated as Fibroblast Triggered Gene Expression in Tumor (FTExT). Prominent features of tumor cell response included transcript rep

ORGANISM(S): Homo sapiens

SUBMITTER: Seok Junhee 

PROVIDER: S-ECPF-GEOD-27018 | biostudies-other |

REPOSITORIES: biostudies-other