Lung cancer signatures in plasma based on proteome profiling of mouse tumor models

ABSTRACT: Mouse models of cancer recapitulate many of the molecular and biological features of the human disease. We sought to exploit these experimental merits in a systematic comparative proteomics search for circulating proteins associated with lung tumor development. In-depth quantitative proteomics was applied to plasmas from three mouse models of lung adenocarcinoma driven by mutant EGFR or Kras or induced by urethane exposure and a mouse model of small cell lung cancer driven by loss of Trp53 and Rb. To further refine our lung cancer-specific and broad carcinoma signatures, we intersected these lung cancer proteome profiles with those from other well-established mouse models of pancreatic, ovarian, colon, prostate and breast cancer, as well as two mouse models of inflammation. A set of prote

ORGANISM(S): Homo sapiens

SUBMITTER: Lockwood William 

PROVIDER: S-ECPF-GEOD-28480 | biostudies-other |

REPOSITORIES: biostudies-other