Transcriptional profiling of lncRNAs and novel transcribed regions across a diverse panel of archived human cancers

ABSTRACT: Molecular characterization of tumors has been critical for identifying important genes in cancer biology and for improving tumor classification and diagnosis. Long non-coding RNAs (lncRNAs), as a new, relatively unstudied class of transcripts, provide a rich opportunity to identify both functional drivers and cancer-type specific biomarkers. However, despite the potential importance of lncRNAs to the cancer field, no comprehensive survey of lncRNA expression across various cancers has been reported. We used 3'-End Sequencing for Expression Quantification (3SEQ) to quantify transcript abundance across 64 solid tumors representing 17 diagnostic subtypes of adenocarcinomas, squamous cell carcinomas, and sarcomas. We identified hundreds of transcripts from among the known 1,065 lncRNAs surveye

ORGANISM(S): Homo sapiens

SUBMITTER: West Robert 

PROVIDER: S-ECPF-GEOD-28866 | biostudies-other |

REPOSITORIES: biostudies-other