Transcription profiling of human invasive breast carcinomas and data analysis from published studies to understand the molecular basis of histologic grade to improve prognosis

ABSTRACT: Background: Histologic grade in breast cancer provides clinically important prognostic information. However, 30%-60% of tumors are classified as histologic grade 2. This grade is associated with an intermediate risk of recurrence and is thus not informative for clinical decision making. We examined whether histologic grade was associated with gene expression profi les of breast cancers and whether such profi les could be used to improve histologic grading. Methods: We analyzed microarray data from 189 invasive breast carcinomas and from three published gene expression datasets from breast carcinomas. We identified differentially expressed genes in a training set of 64 estrogen receptor (ER)-positive tumor samples by comparing expression profiles between histologic grade 3 tumors and histo

ORGANISM(S): Homo sapiens

SUBMITTER: Sotiriou C 

PROVIDER: S-ECPF-GEOD-2990 | biostudies-other | 2006 Feb

REPOSITORIES: biostudies-other