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Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract

ABSTRACT: Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and Agaricus blazei extract (ABE) Two-condition experiment, E2- or ABE-treated vs. control cells. 2 to 3 biological replicates, independently grown and harvested. Two to three replicates per array.

ORGANISM(S): Homo sapiens

SUBMITTER: yun zhu

PROVIDER: S-ECPF-GEOD-30193 | biostudies-other |

REPOSITORIES: biostudies-other

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Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and Agaricus blazei extract (ABE) Two-condition experiment, E2- or ABE-treated vs. control cells. 2 to 3 biological replicates, independently grown and harvested. Two to three replicates per array.

2014-01-01 | E-GEOD-30193 | biostudies-arrayexpress

Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and Agaricus blazei extract (ABE)

2014-01-01 | GSE30193 | GEO

Estrogen-like activity and dual roles in cell signaling of brefeldin A

Project description: Not available

| S-ECPF-GEOD-33851 | biostudies-other

Estrogen-like activity and dual roles in cell signaling of brefeldin A

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and brefeldin A (BFA) Two-condition experiment, E2- or BFA-treated vs. control cells. Two biological replicates, independently grown and harvested. Two replicates per array.

2014-01-01 | E-GEOD-33851 | biostudies-arrayexpress

Estrogen-like activity and dual roles in cell signaling of brefeldin A

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and brefeldin A (BFA)

2014-01-01 | GSE33851 | GEO

Genome Survey and Transcriptome Analysis on Mycelia and Primordia of Agaricus blazei.

Project description: Not available

| S-EPMC6983287 | biostudies-literature

<i>Agaricus bisporus</i> Crude Extract: Characterization and Analytical Application.

Project description: Not available

| S-EPMC7765987 | biostudies-literature

Estrogen-like activity in cell signaling of capsaicinoids

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and capsaicinoids (capsaicin (CAP), dihydrocapsaicin (DHCAP), nordihydrocapsaicin (NDHCAP), nonivamide (NV))

2017-06-13 | GSE64155 | GEO

Estrogen-like activity in cell signaling of lignans

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and lignans (sesamin (SE), enterodiol (ED), enterolactone (EL), matairesinol (MR), pinoresinol (PR)).

2017-03-08 | GSE86565 | GEO

Pancreatic adenocarcinoma cell lines were treated with Agaricus blazei Murrill hot water extract (AbE).

Project description:Pancreatic cancer is one of the most aggressive human malignancies with 7.1% five-year survival rate due to late-stage diagnosis and lack of effective treatment. A novel active compound to be useful for treating pancreatic cancer is absolutely demanded. Agaricus blazei (A. blazei) Murrill has been shown to have an anti-cancer activity, however, its specific efficacy and underlying mechanism is poorly understood. Here, we demonstrated that A. blazei hot water extract (AbE) showed significant growth inhibition of cultured pancreatic cancer cells with less suppressive effect on the normal human pancreatic duct epithelial cells. The pancreatic cancer cells committed G0/G1 cell cycle arrest and caspase-dependent apoptosis. Moreover, we uncovered significant alterations of global gene expression in the pancreatic cancer cells by AbE treatment. Signature of alteration of gene expression indicated that AbE induced repression of genes associated with kinetochore function, spindle formation, centromere maintenance, and cyclins and cyclin dependent kinases, which were essential for cell cycle progression. The gene expression analysis also showed upregulation of proapoptotic genes. These results indicate that AbE could be useful for treatment of pancreatic cancer and a good candidate to isolate potent active compound for development of novel drug for pancreatic cancer.

2018-10-31 | GSE89396 | GEO

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