An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype

ABSTRACT: Regulation of cell-cell junction formation and regulation of cell migration were enriched among EMT (Epithelial-Mesenchymal Transition)-associated alternatively splicing events. Our analysis suggested that most EMT-associated alternative splicing events are regulated by one or more members of the RBFOX, MBNL, CELF, hnRNP or ESRP classes of splicing factors. The EMT alternative splicing signature was confirmed in human breast cancer cell lines, which could be classified into basal and luminal subtypes based exclusively on their EMTassociated splicing pattern. Expression of EMT-associated alternative mRNA transcripts was also observed in primary breast cancer samples, indicating that EMT-dependent splicing changes occur commonly in human tumors. The functional significance of EMT-associated

ORGANISM(S): Homo sapiens

SUBMITTER: Shapiro IM 

PROVIDER: S-ECPF-GEOD-30290 | biostudies-other | 2011 Aug

REPOSITORIES: biostudies-other