Gene expression data from human metastatic melanoma tumors that may predict response to RAF265

ABSTRACT: To determine how mutation of BRAF affected the response to RAF265, we utilized a tumor orthotopic implant model of early passage melanoma tumors in nude mice from a series of 17 patients with advanced metastatic Tumor growth was compared between RAF265 treatment (40 mg/kg, QD) and diluent control groups. The melanoma associated gene mutation profile and global gene expression profile were determined on these human melanoma samples by SNaPshot and Affymetrix Human Gene ST 1.0 Array, respectively. Tumors were evaluated for growth response to RAF265 in an orthotopic implant model using nude mice. Comparisons were made between gene expression profiles of responders and non-responders, BRAF mutant and BRAF wild type tumors. Analysis of the microarray data revealed responders exhibited enriched

ORGANISM(S): Homo sapiens

SUBMITTER: Su Y 

PROVIDER: S-ECPF-GEOD-30812 | biostudies-other | 2012 Apr

REPOSITORIES: biostudies-other