Simultaneous analysis of tumor and stromal gene expression profiles from xenograft models

ABSTRACT: Identifying the gene expression alterations that occur in both the tumor and stroma is essential to understanding tumor biology. We have developed a dual-species microarray analysis method that allows the dissection of both tumor and stromal gene expression profiles from xenograft models, based on limited interspecies cross-hybridization on Illumina gene expression beadchips. This methodology allows for simultaneous genome-wide analysis of gene expression profiles of both tumor cells and the associated stromal tissue. Data is provided regarding the crosshybridization of mouse liver RNA on human microarray, and MDA-MB-231 breast cancer cell line RNA on mouse microarray. Data is also provided for comparisons of MDA-MB-231 gene expression in vitro vs. in vivo, and mouse liver gene expression

ORGANISM(S): Homo sapiens

SUBMITTER: Iorns E 

PROVIDER: S-ECPF-GEOD-30993 | biostudies-other | 2012 Jan

REPOSITORIES: biostudies-other