Gene expression profiling of normal lung tissue adjacent to lung adenocarcinoma (ADCA)

ABSTRACT: Individual variations in the transcriptional profile of normal lung tissue may reflect the lung ADCA patients’ predisposition to a specific clinical stage Associations between clinical outcome of cancer patients and the gene expression signature in primary tumors at time of diagnosis have been reported. To test whether gene expression patterns in the normal tissue surrounding the cancerous tissue might correlate with clinical stage, we compared transcriptome of normal lung samples of adenocarcinoma (ADCA) smoker patients of clinical stage I versus stage >I, and identified 55 differentially expressed genes. Eight out of 10 genes validated by quantitative real-time PCR confirmed statistical association with clinical stage, with 6 genes downregulated in high clinical stage patients, including

ORGANISM(S): Homo sapiens

SUBMITTER: De Cecco Loris 

PROVIDER: S-ECPF-GEOD-31267 | biostudies-other |

REPOSITORIES: biostudies-other