Transcription profiling of human breast cancers

ABSTRACT: Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance to the analysis of cellular signaling pathways central to the oncogenic process. With this focus, we have developed a series of gene expression signatures that reliably reflect the activation status of several oncogenic pathways. When evaluated in several large collections of human cancers, these gene expression signatures identify patterns of pathway deregulation in tumors, and clinically relevant associations with disease outcomes. Combining signature-based predictions across several pathways

ORGANISM(S): Homo sapiens

SUBMITTER: Bild AH 

PROVIDER: S-ECPF-GEOD-3143 | biostudies-other | 2006 Jan

REPOSITORIES: biostudies-other