Stem-like glioma-propagating cells contribute to molecular heterogeneity and survival outcome in oligodendroglial tumors

ABSTRACT: Brain tumors are among the most malignant cancers and can arise from neural stem cells or oligodendrocyte progenitor cells (OPCs). Glioma-propagating cells (GPCs) that have stem-like properties have been derived from tumor variants such as glioblastoma multiforme (GBM) and oligodendroglial tumors, the latter being more chemosensitive with better prognosis. It has been suggested that such differences in chemosensitivity arise from the different profiles of OPCs versus neural stem cells. We thus explored if GPCs derived from these glioma variants can serve as reliable in vitro culture systems for studies. We utilized gene expression analyses, since GBM and oligodendrogliomas can be molecularly classified. Accordingly, we derived a gene signature distinguishing oligodendroglial GPCs from GBM

ORGANISM(S): Homo sapiens

SUBMITTER: Ng Felicia 

PROVIDER: S-ECPF-GEOD-31545 | biostudies-other |

REPOSITORIES: biostudies-other