Transcription profiling of human breast cancer cell lines to investigate p53 status in breast cancer

ABSTRACT: Breast cancer subtypes identified in genomic studies have different underlying genetic defects. Mutations in the tumor suppressor p53 occur more frequently in estrogen receptor (ER) negative, basal-like and HER2-amplified tumors than in luminal, ER positive tumors. Thus, because p53 mutation status is tightly linked to other characteristics of prognostic importance, it is difficult to identify p53's independent prognostic effects. The relation between p53 status and subtype can be better studied by combining data from primary tumors with data from isogenic cell line pairs (with and without p53 function). In this study, the p53-dependent gene expression signatures of four cell lines (MCF-7, ZR-75-1, and two immortalized human mammary epithelial cell lines) were identified by comparing p53

ORGANISM(S): Homo sapiens

SUBMITTER: Troester MA 

PROVIDER: S-ECPF-GEOD-3178 | biostudies-other | 2006

REPOSITORIES: biostudies-other