Gene expression profiles of Glioblastoma stem cells in which ALK or pleiotrophin expression was suppressed

ABSTRACT: Cancer stem cells are believed to be responsible for tumor initiation and development. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma stem cells. Anaplastic lymphoma kinase (ALK) and its ligand pleiotrophin are required for maintaining the stem-like properties and tumorigenicity of glioblastoma stem cells. Human glioblastoma stem cells (GB2) were infected with a lentivirus expressing an shRNA targeting ALK or pleiotrophin.

ORGANISM(S): Homo sapiens

SUBMITTER: Akiyama Tetsu 

PROVIDER: S-ECPF-GEOD-32482 | biostudies-other |

REPOSITORIES: biostudies-other