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Expression data from paired matched breast cancer Fine needle aspiration (FNA) or Core needle biopsies (CBX)

ABSTRACT: Paired FNA and CBX specimens were prospectively collected from 37 breast cancers before any systemic therapy during a biomarker discovery study at The University of Texas M. D. Anderson Cancer Center. We identified 293 probe sets overexpressed in core biopsies; these included five highly coexpressed gene clusters (metagenes) corresponding to immune functions and extracellular matrix components. We compared gene expression profiles of pairs of fine-needle (stroma-poor) and core-needle (stroma-rich) biopsies from 37 cancers to identify stroma-associated genes Pre-treatment paird matched FNA and CBX from primary tumors were obtained and RNA extracted and hybridized to afymetrix microarrays according to manufacturer protocol.

ORGANISM(S): Homo sapiens

SUBMITTER: Bianchini G

PROVIDER: S-ECPF-GEOD-32518 | biostudies-other | 2010 Oct

REPOSITORIES: biostudies-other

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