Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer [mRNA]

ABSTRACT: To perform an integrative profile of human pancreatic cancer (PDAC) to identify prognosis-significant genes and their related pathways. A concordant survival-based whole genome in silico array analysis of DNA copy number, and mRNA & micro RNA (miRNA) expression in 25 early stage PDAC was performed. A novel composite score simultaneously integrated gene expression with regulatory mechanisms to identify the signature genes with the most levels of prognosis-significant evidence. The predominant signaling pathways were determined via a pathway-based approach. Independent patient cohorts (n= 150 and 42) were then used as in vitro validation of the array findings. We find that EGFR, SRC signaling, and PI3K/AKT pathway activation are strongly linked to clinical disease progression. Furthermore,

ORGANISM(S): Homo sapiens

SUBMITTER: Tran Linh 

PROVIDER: S-ECPF-GEOD-32676 | biostudies-other |

REPOSITORIES: biostudies-other