Gene expression analysis of lung adenocarcinoma and matched adjacent non-tumor lung tissue

ABSTRACT: Gene expression profiling of 60 lung adenocarcinoma tumors and their matched histologically normal adjacent lung tissue samples were analyzed using Illumina HumanWG-6 v3.0 expression beadchip. We integrated these data with DNA methylation profiles of the same samples to identify potential DNA methylation regulated genes. Lung cancer is the leading cause of cancer death worldwide and adenocarcinoma is its most common histological subtype. Clinical and molecular evidence indicates that lung adenocarcinoma is a heterogeneous disease, which has important implications for treatment. Here we performed genome-scale DNA methylation profiling using the Illumina Infinium HumanMethylation27 platform on 59 matched lung adenocarcinoma/non-tumor lung samples, with genome-scale verification on an indepen

ORGANISM(S): Homo sapiens

SUBMITTER: Laird-Offringa Ite 

PROVIDER: S-ECPF-GEOD-32863 | biostudies-other |

REPOSITORIES: biostudies-other