Modeling lethal prostate cancer variant with small cell carcinoma features [expression profile]

ABSTRACT: Purpose: Small-cell prostate carcinoma (SCPC) morphology predicts for a distinct clinical behavior, resistance to androgen ablation, and frequent but short responses to chemotherapy. The model systems we report reflect the biology of the human disease and can be used to improve our understanding of SCPC and to develop new therapeutic strategies for it. Experimental Design: We developed a set of CRPC xenografts and examined their fidelity to their human tumors of origin. We compared the expression and genomic profiles of SCPC and large cell neuroendocrine carcinoma (LCNEC) xenografts to those of typical prostate adenocarcinoma xenografts and used a panel of 60 human tumors to validate our findings using immunohistochemistry. Results: We show that SCPC and LCNEC xenograft models retain high

ORGANISM(S): Homo sapiens

SUBMITTER: Zhang Jiexin 

PROVIDER: S-ECPF-GEOD-32967 | biostudies-other |

REPOSITORIES: biostudies-other