?Seed-milarity? confers to hsa-miR-210 and hsa-miR-147b similar functional activity

ABSTRACT: Specificity of interaction between a microRNA (miRNA) and its targets crucially depends on the seed region located in its 5’-end. It is often implicitly considered that two miRNAs sharing the same biological activity should display similarity beyond the strict six nucleotide region that forms the seed, in order to form specific complexes with the same mRNA targets. We have found that expression of hsa-miR-147b and hsa-miR-210, though triggered by different stimuli (i.e. lipopolysaccharides and hypoxia, respectively), induce very similar cellular effects in term of proliferation, migration and apoptosis. Hsa-miR-147b only shares a “minimal” 6-nucleotides seed sequence with hsa-miR-210, but is identical with hsa-miR-147a over 20 nucleotides, except for one base located in the seed region. Ph

ORGANISM(S): Homo sapiens

SUBMITTER: Lebrigand Kevin 

PROVIDER: S-ECPF-GEOD-33247 | biostudies-other |

REPOSITORIES: biostudies-other