Oncogenic PI3K mutations lead to NF-kB-dependent cytokine expression following growth

ABSTRACT: While growth factor-independent signaling and proliferation are well-established hallmarks of cancer, little is known regarding growth factor-independent changes in gene expression which occur downstream from oncogenes. The PI3K pathway is one of the most commonly misregulated signaling pathways in human cancers. Here, MCF10A cells expressing the two most common PI3K mutations, PIK3CA E545K and H1047R, were used to identify the repertoire of genes altered by oncogenic PI3K mutations following growth factor deprivation. This gene set most closely correlated with gene signatures from claudin-low and basal-like breast tumors, and categorical enrichment analyses suggested that NF-kB target genes were dramatically upregulated by these mutations. An IKKb inhibitor was used to identify the subset

ORGANISM(S): Homo sapiens

SUBMITTER: Perou Charles 

PROVIDER: S-ECPF-GEOD-33403 | biostudies-other |

REPOSITORIES: biostudies-other