Whole genome expression profile of lung epithelial cells following chronic arsenic exposure

ABSTRACT: This study chronically exposed human lung epithelial BEAS-2B cells to low-dose arsenic trioxide in vitro to elucidate cancer promoting gene signaling networks (GSNs) associated with As-transformed (B-As) cells. Following a six month exposure, exposed cells were assessed for enhanced cell proliferation, colony formation, invasion ability and in vivo tumor formation compared to control cell lines. Collected mRNA was subjected to whole genome expression microarray profiling followed by in silico Ingenuity Pathway Analysis (IPA) to identify lung carcinogenesis modes of action. B-As cells displayed significant increases in proliferation, colony formation and invasion ability compared to BEAS-2B cells. B-As injections into nude mice resulted in development of primary and secondary metastati

ORGANISM(S): Homo sapiens

SUBMITTER: Stueckle TA 

PROVIDER: S-ECPF-GEOD-33520 | biostudies-other | 2012 Jun

REPOSITORIES: biostudies-other