Comparison of gene expression alterations induced by distinct PI3K inhibitors

ABSTRACT: The goal is the characterization of the off-target activity of BKM120 observed in A2058 human melanoma cell line at IC90 concentration (3.606 µM) but not at lower concentrations. Controls are BEZ235, GDC0941, showing no off-target activity. A secondary objective is the characterizations of drug effects on transcript expression with respect to a control treatment (DMSO) of those PI3K inhibitors. 3 compounds, 3 concentrations per compound treatment, DMSO control treatement, 4 biological replicates

ORGANISM(S): Homo sapiens

SUBMITTER: Brachmann SM 

PROVIDER: S-ECPF-GEOD-33643 | biostudies-other | 2012 Aug

REPOSITORIES: biostudies-other