Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcomatic cells: a systems biology approach

ABSTRACT: "A part of current research has intensively been focused on the proliferation and metabolic processes governing biological systems. Since the advent of high throughput methodologies like microarrays, the load of genomic data has increased geometrically and along with that the need for computational methods which will interpret these data. In the present work we study in vitro the common proliferation and metabolic processes, which are combined to the common oncogenic pathways, as far as gene expression is concerned, between the T-cell acute lymphoblastic leukemia (CCRF-CEM) and the rhabdomyosarcoma (TE-671) cell lines. We present a computational approach, using cDNA microarrays, in order to identify commonalities between diverse biological systems. Our analysis predicted that JAK1, STAT1,

ORGANISM(S): Homo sapiens

SUBMITTER: Lambrou George 

PROVIDER: S-ECPF-GEOD-34522 | biostudies-other |

REPOSITORIES: biostudies-other