Gene Expression in Normal and Tumor Ovarian Epithelial Cells from Non-carriers and Heterozygous Carriers of a BRCA French Canadian Mutation

ABSTRACT: We hypothesized that the transcriptome of primary cultures of morphologically normal ovarian surface epithelial cells could be altered by the presence of a heterozygous BRCA1 or BRCA2 mutation. We aimed to discover early events associated to ovarian carcinogenesis, which could represent putative targets for preventive strategies of this silent killer tumor. We identified the first molecular signature associated with French Canadian BRCA1 or BRCA2 founder mutations in morphologically normal ovarian epithelial cells. We discovered that wild-type and mutated BRCA2 allelic transcripts were expressed not only in morphologically normal but also in tumor cells from 8765delAG BRCA2 carriers. Further analysis of morphologically normal ovarian and tumor cells from C4446T BRCA1 carriers lead to the

ORGANISM(S): Homo sapiens

SUBMITTER: Abd-Rabbo D 

PROVIDER: S-ECPF-GEOD-34928 | biostudies-other | 2012 May

REPOSITORIES: biostudies-other