MicroRNA expression analysis of tumor tropic mesenchymal stem cells

ABSTRACT: The subpopulations of mesenchymal stem cells isolated from breast adipose tissue which display migrated towards conditioned media from MDA-MB231 cell line were expanded for miRNA analysis. The tumor microenvironment (TM) is known to promote tumor growth and progression. Ubiquitously distributed tissue resident stem cells (MSCs) elicit regenerative properties. In addition, they are capable of homing to sites of inflammation, injury, and tumor. Considering the tumor tropic property of MSCs, the interaction between the breast cancer (BC) microenvironment and breast resident adipose tissue derived MSCs (ASCs) merits further investigations. Initial data indicate that a subset of ASCs derived from breast adipose tissue (B-ASCs) display a high affinity towards the conditioned media (CM) from two

ORGANISM(S): Homo sapiens

SUBMITTER: Izadpanah Reza 

PROVIDER: S-ECPF-GEOD-35901 | biostudies-other |

REPOSITORIES: biostudies-other