Contribution of microRNA-1275 to Claudin11 suppression via polycomb-mediated silencing mechanism in human glioma stem-like cells

ABSTRACT: Glioblastomas show heterogeneous histological features, in which tumor cells show distinct phenotypic states that confer different functional attributes. This functional and morphological heterogeneity characterizes aggressive glioblastoma; however, molecular mechanisms underlying the heterogeneity are poorly understood. Glioma stem-like cells (GSCs) are considered able to aberrantly differentiate into diverse cell types and may contribute the establishment of tumor heterogeneity. Using the GSC model, we investigated the differentially expressed microRNAs(miRNAs) and associated epigenetic mechanism that regulate the differentiation of GSCs. MiRNA-microarray showed that 13 and 34 miRNAs were commonly upregulated and downregulated in two independent GSC lines during differentiation, respecti

ORGANISM(S): Homo sapiens

SUBMITTER: Katsushima Keisuke 

PROVIDER: S-ECPF-GEOD-36201 | biostudies-other |

REPOSITORIES: biostudies-other