Gene expression profiling of enforced HOXA1 expression in melanoma cell line

ABSTRACT: We recently reported an oncogenomics-guided screening approach designed to identify genetic drivers of early stage melanoma metastasis, and in this study we functionally validate the top-scoring candidate, homeobox transcription factor A1 (HOXA1), by demonstrating HOXA1‘s robust effects on melanoma cell invasion, metastasis and tumorigenicity. Transcriptome and pathway profiling analyses of cells expressing HOXA1 reveal up-regulation of factors involved in diverse cytokine pathways that include the TGFβ signaling axis, which we further demonstrate to be required for HOXA1-mediated cell invasion. Transcriptome profiling also informed HOXA1’s ability to potently down-regulate expression of microphthalmia-associated transcription factor (MITF) and other genes required for melanocyte differe

ORGANISM(S): Homo sapiens

SUBMITTER: Wardwell-Ozgo J 

PROVIDER: S-ECPF-GEOD-37136 | biostudies-other | 2014 Feb

REPOSITORIES: biostudies-other