Human breast cancer invasion signature

ABSTRACT: Introduction: Metastasis of breast cancer is the main cause of death in patients. Previous genome-wide studies have identified gene expression patterns correlated with cancer patient outcome, however these were mostly derived from whole tissue without respect to cell heterogeneity. In reality, only a small subpopulation of migratory and invasive cells inside the primary tumor is responsible for escaping and initiating dissemination and metastasis. When whole tissue is used for molecular profiling, the expression pattern of these cells is masked by the majority of the non-invasive tumor cells. Therefore, little information is available about the crucial early steps of the metastatic cascade: migration, invasion and entry of tumor cells into the systemic circulation. Method: In the past, we

ORGANISM(S): Homo sapiens

SUBMITTER: Patsialou Antonia 

PROVIDER: S-ECPF-GEOD-37733 | biostudies-other |

REPOSITORIES: biostudies-other