Decreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer

ABSTRACT: Breast cancer is the most common malignancy that develops in women, responsible for the highest cancer-associated death rates. Triple negative breast cancers (TNBC) represent an important subtype that have an aggressive clinical phenotype, are associated with a higher likelihood of metastasis and are not responsive to current targeted therapies. miRNAs have emerged as an attractive candidate for molecular biomarkers and treatment targets in breast cancer, but their role in the progression of TNBC remains largely unexplored. This study has investigated miRNA expression profiles in 31 primary TNBC cases and in 13 lymph node metastases compared with 23 matched normal breast tissues to determine miRNAs associated with the initiation of this disease subtype and those associated with its metasta

ORGANISM(S): Homo sapiens

SUBMITTER: Avery-Kiejda KA 

PROVIDER: S-ECPF-GEOD-38167 | biostudies-other | 2014

REPOSITORIES: biostudies-other