MicroRNA expression patterns of lung metastasis samples distinguish patients with high vs. low rates of metastasis

ABSTRACT: Background: Many strategies to define subtypes and treat cancer relies on a presumption of either localized or widespread (poly)metastatic disease. We proposed an intermediate state of metastasis termed oligometastasis(es) characterized by limited metastatic progression and amenable to treatment by localized methods e.g. surgery or radiotherapy. Methods: To understand the biological basis of oligometastatic and polymetastatic progression, we analyzed microRNA expression patterns from lung tumor samples of patients with less than five metastases at first metastasis presentation and treated with metastasis-directed surgery. Results: Patients were stratified into four subgroups of oligo- and poly-metastatic progression based on the rate of metastatic progression over follow-up period. We prio

ORGANISM(S): Homo sapiens

SUBMITTER: Li Jianrong 

PROVIDER: S-ECPF-GEOD-38698 | biostudies-other |

REPOSITORIES: biostudies-other