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HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE38232: HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [gene expression] GSE38901: HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [ChIP-Seq] Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Mendillo ML

PROVIDER: S-ECPF-GEOD-38912 | biostudies-other | 2012 Aug

REPOSITORIES: biostudies-other

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HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

Project description:This SuperSeries is composed of the following subset Series: GSE38232: HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [gene expression] GSE38901: HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [ChIP-Seq] Refer to individual Series

2012-08-06 | E-GEOD-38912 | biostudies-arrayexpress

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

Project description:This SuperSeries is composed of the SubSeries listed below.

2012-08-07 | GSE38912 | GEO

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [gene expression]

Project description:Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the transcriptional network that HSF1 coordinates directly in malignancy and its relationship to the heat-shock response have never been defined. By comparing cells with high and low malignant potential alongside their non-transformed counterparts, we identify an HSF1-regulated transcriptional program specific to highly malignant cells and distinct from heat shock. Cancer-specific genes in this program support oncogenic processes: cell-cycle regulation, signaling, metabolism, adhesion and translation. HSP genes are integral to this program, however, even these genes are uniquely regulated in malignancy. This HSF1 cancer program is active in breast, colon and lung tumors isolated directly from human patients and is strongly associated with metastasis and death. Thus, HSF1 rewires the transcriptome in tumorigenesis, with prognostic and therapeutic implications. We used microarrays to examine affect of HSF1 depletion on gene expression in cancer cell lines. Three cancer cell lines (BPLER, HMLER & MCF7) were transduced with either control shRNAi (Scramble or GFP) or an shRNAi that targets and depletes HSF1 (hA6). Another BPLER sample was subjected to a 1H, 42M-KM-^Z C heat shock. Two biological replicates for all samples.

2012-08-06 | E-GEOD-38232 | biostudies-arrayexpress

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [ChIP-Seq]

2012-08-07 | E-GEOD-38901 | biostudies-arrayexpress

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [gene expression]

2012-08-07 | GSE38232 | GEO

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [ChIP-Seq]

2012-08-07 | GSE38901 | GEO

E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response.

Project description: Not available

| S-EPMC5066613 | biostudies-literature

Heat Shock Factor 1 Drives Intergenic Association of Its Target Gene Loci upon Heat Shock.

Project description: Not available