Downstream targets of ID1 transcription factor in Non-Small Cell Lung Carcinoma (NSCLC)

ABSTRACT: ID-1, known as inhibitor of differentiation or a helix loop helix transcription factor which lack the basic DNA binding domain. It is known to bind to bHLH transcription factor and inhibit those bHLH to bind to the promoter thus inhibiting further transcription. Overexpression of ID-1 has been correlated with a variety of human cancers including breast, prostate, pancreatic, ovarian, endometrial, bladder cancer and melanomas. Recently known that if ID-1 is depleted, it abrogates cell proliferation, invasion and migration of cells in NSCLC. Further ID-1 expression is induced by Nicotine and EGF through the activation of nAChRs and EGFR. Here microarray analysis was done to compare differential gene expression patterns upon nicotine and EGF stimulation of A549 and H1650 cells and how ID1 dep

ORGANISM(S): Homo sapiens

SUBMITTER: Perumal Deepak 

PROVIDER: S-ECPF-GEOD-38944 | biostudies-other |

REPOSITORIES: biostudies-other