Synthetic lethal screening with small molecule inhibitors provides a pathway to rational combination therapies for melanoma

ABSTRACT: Recent data demonstrate that extracellular signals are transmitted through a network of proteins rather than hierarchical signaling pathways. This network model suggests why inhibition of a single component of a canonical pathway, even when targeting a mutationally activated driver of cancer, has insufficiently dramatic effects on the treatment of cancer. The biological outcome of signals propagated through a network is inherently more robust and resistant to inhibition of a single network component due to compensatory and redundant signaling events. In this study, we performed a functional chemical genetic screen analogous to synthetic lethal screening in yeast genetics to identify novel interactions between signaling inhibitors that would not be predicted based on our current understand

ORGANISM(S): Homo sapiens

SUBMITTER: Roller DG 

PROVIDER: S-ECPF-GEOD-39192 | biostudies-other | 2012 Nov

REPOSITORIES: biostudies-other