MiRNA analysis of triple-negative breast cancers in association with clinical and molecular phenotypes

ABSTRACT: Background: This study focuses on the analysis of miRNAs expression data in a cohort of 181 well characterised breast cancer samples composed primarily of triple-negative (ER/PR/HER2-negative) tumours with associated genome-wide DNA and mRNA data, extensive patient follow-up and pathological information. Results: We identified 7 miRNAs with a prognostic role in the triple-negative tumours and an additional 8 prognostic miRNAs when the analysis was extended to the set of all ER-negative cases. miRNAs linked to an unfavourable prognosis were associated with a broad spectrum of motility mechanisms involved in the invasion of stromal tissues, such as cell-adhesion, growth factor-mediated signalling pathways, interaction with the extracellular matrix and cytoskeleton remodelling. When we compar

ORGANISM(S): Homo sapiens

SUBMITTER: Burford Brian 

PROVIDER: S-ECPF-GEOD-40267 | biostudies-other |

REPOSITORIES: biostudies-other