FC-IBC-02: A New in vitro-in vivo Model of Triple Negative Inflammatory Breast Cancer

ABSTRACT: Inflammatory breast cancer (IBC) is the most aggressive type of advanced breast cancer and is associated with a poor prognosis. We have developed a new model of IBC derivated from the pleural effusion of a 49-year-old woman with metastatic secondary IBC. FC-IBC02 tumor cells were isolated from the pleural effusion and cultured under non-adherent conditions, resulting in the formation of spheroids or mammospheres. FC-IBC02 are triple negative (estrogen receptor negative, progesterone receptor negative and ErbB2 negative) and strongly positive for E-cadherin, beta-catenin and vimentin. FC-IBC02 cells developed breast tumors when they were injected into the mammary fat pad of SCID mice and characteristic tumor emboli were detected. Breast tumor xenografts were poorly differentiated triple neg

ORGANISM(S): Homo sapiens

SUBMITTER: Huang Yong 

PROVIDER: S-ECPF-GEOD-40464 | biostudies-other |

REPOSITORIES: biostudies-other