Targeting the Phosphoinositide 3-Kinase p110? Isoform Impairs Cell Proliferation, Survival and Tumor Growth in Small Cell Lung Cancer

ABSTRACT: Purpose: The phosphoinositide 3-kinase (PI3K) pathway is fundamental for cell proliferation and survival and is frequently altered and activated in neoplasia, including carcinomas of the lung. In this study we investigated the potential of targeting the catalytic class IA PI3K isoforms in small cell lung cancer (SCLC), which is the most aggressive of all lung cancer types. Experimental Design: The expression of PI3K isoforms in patient specimens was analyzed. The effects on SCLC cell survival and downstream signaling were determined following PI3K isoform inhibition by selective inhibitors or down-regulation by small interfering RNA. Results: Over-expression of the PI3K isoforms p110 -alpha and p110-alpha was shown by immunohistochemistry in primary SCLC tissue samples. Targeting the PI3

ORGANISM(S): Homo sapiens

SUBMITTER: Rehrauer Hubert 

PROVIDER: S-ECPF-GEOD-40564 | biostudies-other |

REPOSITORIES: biostudies-other