A radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced adverse side effects

ABSTRACT: The majority of patients tolerate radiotherapy well, but some of them suffer from severe side effects. To find genes possibly predictive for radiosensitivity, mRNA profiles were generated before and 6 h after in vitro irradiation with 5 Gy. We analyzed lymphocytes from four head and neck and eight breast cancer patients with strong acute radiation toxicity and from 12 matching normal reacting patients in a blind study. In peripheral blood lymphocytes of all patients, 153 genes were identified which were statistically significantly altered by a fold change of more than 50% by irradiation. Pathway analysis revealed genes involved in p53 signalling, cell cycle control and apoptosis in response to radiation in primary lymphocytes. In these cells, a set of 67 radiation-induced genes was identif

ORGANISM(S): Homo sapiens

SUBMITTER: Schmezer Peter 

PROVIDER: S-ECPF-GEOD-40640 | biostudies-other |

REPOSITORIES: biostudies-other