Transcriptional profiling of human cancer cell lines upon ZMPSTE24 silencing

ABSTRACT: Defining the aging-cancer relationship is a challenging task. Mice deficient in Zmpste24, a metalloproteinase mutated in human progeria and involved in nuclear prelamin A maturation, recapitulate many features of aging. However, their short lifespan and cell-intrinsic and -extrinsic alterations restrict the application and interpretation of carcinogenesis protocols. To circumvent these limitations we have generated Zmpste24 mosaic mice. Interestingly, these mice develop normally - revealing cell-extrinsic mechanisms are preeminent in progeria- and display decreased incidence of infiltrating oral carcinomas. Moreover, ZMPSTE24 knock-down reduces human cancer cell invasiveness. Our results disclose the ZMPSTE24-prelamin A system as an example of antagonistic pleiotropy on cancer and aging, s

ORGANISM(S): Homo sapiens

SUBMITTER: de la Rosa Jorge 

PROVIDER: S-ECPF-GEOD-41799 | biostudies-other |

REPOSITORIES: biostudies-other