Clinical Utility of Circulating MicroRNA Signatures for Breast Cancer Diagnosis (RT-PCR)

ABSTRACT: Purpose: There is a quest for novel non-invasive diagnostic markers for the detection of breast cancer. The goal of this study is to identify circulating microRNA signatures using a cohort of Asian Chinese breast cancer patients, and to compare microRNA profiles between tumour and serum samples. Experimental design: MicroRNAs from paired breast cancer tumours, normal tissue and serum samples derived from 32 patients were comprehensively profiled using microarrays (1300 microRNAs against tumour and normal tissues) or LNA RT-PCR panels (742 microRNAs against serum samples). Serum samples from healthy individuals (n=22) were also employed as normal controls. Significant serum microRNAs, identified by logistic regression, were validated in an independent set of serum samples from patients (n

ORGANISM(S): Homo sapiens

SUBMITTER: Chan M 

PROVIDER: S-ECPF-GEOD-41922 | biostudies-other | 2013 Aug

REPOSITORIES: biostudies-other