Two New Stromal Signatures Stratify Breast Cancers with Different Prognosis

ABSTRACT: Purpose: Multiple studies from last decades have shown that the microenvironment of carcinomas plays an important role in the initiation, progression and metastasis of cancer. Our group has previously identified novel cancer stroma gene expression signatures associated with outcome differences in breast cancer by gene expression profiling of two tumors of fibroblasts as surrogates for physiologic stromal expression patterns. The aim of this study is to find additional new types of tumor stroma gene expression patterns. Results: 53 tumors were sequenced by 3SEQ with an average of 29 million reads per sample. Both the elastofibroma (EF) and fibroma of tendon sheath (FOTS) gene signatures demonstrated robust outcome results for survival in the four breast cancer datasets. The EF signatu

ORGANISM(S): Homo sapiens

SUBMITTER: Guo Xiangqian 

PROVIDER: S-ECPF-GEOD-42948 | biostudies-other |

REPOSITORIES: biostudies-other