Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells

ABSTRACT: Understanding transcriptional changes during cancer progression is of crucial importance to develop new and more efficacious diagnostic and therapeutic approaches. It is well known that ErbB2 is overexpressed in about 25% of human invasive breast cancers. We have previously demonstrated that p130Cas overexpression synergizes with ErbB2 in mammary cell transformation and promotes ErbB2-dependent invasion in three-dimensional (3D) cultures of human mammary epithelial cells. Here, by comparing coding and non-coding gene expression profiles, we define the invasive signatures associated with concomitant p130Cas overexpression and ErbB2 activation in 3D cultures of mammary epithelial cells. Specifically, we have found that genes involved in amino acids synthesis (CBS, PHGDH), cell motility, migr

ORGANISM(S): Homo sapiens

SUBMITTER: Pincini A 

PROVIDER: S-ECPF-GEOD-42949 | biostudies-other | 2013 Aug

REPOSITORIES: biostudies-other