A BRCA1 Deficient-Like Signature is Enriched in Breast Cancer Brain Metastases

ABSTRACT: Purpose: There is an unmet clinical need for biomarkers to identify breast cancer patients who are at increased risk of developing brain metastases. The objective is to identify gene signatures and biological pathways associated with HER2+ brain metastasis. Experimental Design: Gene expression of 19 HER2+ breast cancer brain metastases was compared with HER2+ nonmetastatic primary tumors. Gene Set Enrichment Analysis was used to identify a signature, which was evaluated for correlation with BRCA1 mutation status and clinical outcome using published microarray datasets and for correlation with pharmacological inhibition by a PARP inhibitor and temozolomide using published microarray datasets of breast cancer cell lines. Results: A BRCA1 Deficient-Like (BD-L) gene signature is significantl

ORGANISM(S): Homo sapiens

SUBMITTER: Wittner Ben 

PROVIDER: S-ECPF-GEOD-43837 | biostudies-other |

REPOSITORIES: biostudies-other