Expression data by BRD7552 treatment in PANC-1 cells
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ABSTRACT: Three master regulatory transcription factors Pdx1, MafA and Ngn3 have the ability to transdifferentiate pancreatic acinar cells to insulin-producing beta cells in mice. BRD7552 was identified as a small-molecule inducer that can upregulate the expression of Pdx1 in PANC-1 cells by high-throughput qPCR screening. We used microarrays to illustrate the mechnism of BRD7552 for PDX1 and insulin induction. PANC-1 cells were treated with BRD7552 at 5uM, the mininal concentration for the maximal induction of Pdx1. The RNA was isloated at two time points 6-hour and 72-hour.
ORGANISM(S): Homo sapiens
SUBMITTER: Yuan Y
PROVIDER: S-ECPF-GEOD-44946 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
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