Identification of oral carcinoma miRNA involved in Wnt/b-catenin signaling

ABSTRACT: MicroRNAs (miRNAs) participate in many biological processes and have emerged as key players in carcinogenesis. In order to identify changes in miRNAs specific for betelquid-associated oral squamous cell carcinoma (OSCC), we investigated the expression profiles of 858 miRNAs in a panel of 40 pairs of OSCC specimens and their matched non-tumorous epithelial counterparts. Eighty-four miRNAs were differentially expressed in the OSCC specimens compared to the matched tissue. Among these miRNAs, 19 downregulated miRNAs located in the chromosome 14q32.2 miRNA cluster region were analyzed. This miRNA cluster resides within a parentally imprinted region known to be important in development and growth. The re-expression of miR-329 and miR-410from this cluster significantly reduced OSCC cell prolifer

ORGANISM(S): Homo sapiens

SUBMITTER: Shiah SG 

PROVIDER: S-ECPF-GEOD-45238 | biostudies-other | 2014 Dec

REPOSITORIES: biostudies-other