Hypoxia-responsive gene expression profile of U87 MG glioblastoma cells and their exosomes

ABSTRACT: How cancer cells adapt to hypoxia during tumor development remains an important question. The hypothesis tested in the present study was that tumor cell-derived exosome vesicles (also known as microvesicles or extracellular vesicles) are mediators of hypoxia-dependent intercellular signaling in glioblastoma (GBM), i.e. highly aggressive brain tumors characterized by hypoxia and a vascular density that is among the highest of all human malignancies. In vitro hypoxia experiments and studies with patient materials reveal the enrichment in exosomes of hypoxia-regulated mRNAs and proteins, several of which were associated with poor patient prognosis. We show that cancer cell exosomes mediate hypoxia-dependent, phenotypic modulation of stromal cells in vitro and ex vivo, resulting in accelerate

ORGANISM(S): Homo sapiens

SUBMITTER: Kucharzewska Paulina 

PROVIDER: S-ECPF-GEOD-45301 | biostudies-other |

REPOSITORIES: biostudies-other