MiR-18a modulates gene transcription in breast cancer cells treated with Cobalt(II) chloride

ABSTRACT: Using the orthotopic breast cancer xenograft model of basal-like breast cancer MDA-MB-231 line, we have found that the expression of miRNAs encoded by MIR17HG was significantly decreased in cells isolated from spontaneous lung metastases compared to cells from primary tumors grown in orthotopic sites. We investigated the role of a MIR17HG family member, miR-18a, in primary tumor growth and pulmonary metastasis from the orthotopic site. We demonstrated that enforced expression of exogenous miR-18a, significantly limited continuous growth of primary tumors in mammary gland fat pads and reduced spontaneous lung metastasis. Further investigation on the mechanism of miR-18a action led to the finding that the expression of HIF1A, a key regulator of tumor metastasis, was regulated by miR-18a. Enf

ORGANISM(S): Homo sapiens

SUBMITTER: Fan Meiyun 

PROVIDER: S-ECPF-GEOD-45362 | biostudies-other |

REPOSITORIES: biostudies-other