Browse
Submit Data
Databases
API
Help

Dataset Information

5 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human melanoma samples comparing nevi and primary and metastatic melanoma

ABSTRACT: We sought to identify genes and gene signatures which correlate with progression by sampling human melanomas from nevi, primary, and metastatic tumors. The large number of samples also permits analysis within groups. Human melanoma samples were isolated from historical frozen patient specimens. RNA was extracted and run on the human Affymetrix U133A microarray chip.

ORGANISM(S): Homo sapiens

SUBMITTER: Kwong Lawrence

PROVIDER: S-ECPF-GEOD-46517 | biostudies-other |

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

Human melanoma samples comparing nevi and primary and metastatic melanoma

2013-05-01 | GSE46517 | GEO

Human melanoma samples comparing nevi and primary and metastatic melanoma

Project description:We sought to identify genes and gene signatures which correlate with progression by sampling human melanomas from nevi, primary, and metastatic tumors. The large number of samples also permits analysis within groups. Human melanoma samples were isolated from historical frozen patient specimens. RNA was extracted and run on the human Affymetrix U133A microarray chip.

2013-05-01 | E-GEOD-46517 | biostudies-arrayexpress

The Interplay between Nevi and Melanoma Predisposition Unravels Nevi-Related and Nevi-Resistant Familial Melanoma.

Project description: Not available

| S-EPMC8303673 | biostudies-literature

miR-193b represses cell proliferation and regulates cyclin D1 in melanoma: benign nevi and metastatic melanoma

Project description: Not available

| S-ECPF-GEOD-18509 | biostudies-other

NRAS and BRAF mutations in melanoma-associated nevi and uninvolved nevi.

Project description: Not available

| S-EPMC3704624 | biostudies-literature

Transcription profiling of human common melanocytic nevi, radial and vertical growth phase melanomas, melanoma metastases and dysplastic nevi

Project description: Not available

| S-ECPF-GEOD-12391 | biostudies-other

miR-193b represses cell proliferation and regulates cyclin D1 in melanoma: benign nevi and metastatic melanoma

Project description:Cutaneous melanoma is an increasingly common form of skin cancer. The molecular mechanisms regulating melanoma progression are not completely understood. We speculated that specific miRNAs may be involved in melanoma development. We compared the miRNA expression profiles of benign nevi and metastatic melanomas. Unsupervised hierarchical clustering demonstrated a distinct miRNA expression pattern in metastatic melanomas compared to nevi. We identified miRNAs that were differentially expressed in melanoma. Notably, miR-193b was significantly down-regulated in the melanoma tissue examined. Using functional studies we demonstrated that over-expression of miR-193b significantly reduced melanoma cell proliferation, and arrested cell at G1 phase. Further gene expression analysis revealed that miR-193b regulated targets involved in cell cycle. Cyclin D1 was down-regulated by miR-193b at both the mRNA and protein level. This is the first study to show that the miR-193b may reduce cell proliferation by directly repressing cyclin D1. Overall, our study suggests that miRNAs are dysregulated in metastatic melanoma, and that miR-193b may play an important role in melanoma.

2009-12-20 | GSE18509 | GEO

miR-193b represses cell proliferation and regulates cyclin D1 in melanoma: benign nevi and metastatic melanoma

2010-05-16 | E-GEOD-18509 | biostudies-arrayexpress

Long non-coding RNA expression profile of primary melanoma versus nevi

Project description:To explore the role of long non-coding RNAs (lncRNAs) in melanoma progression, we performed lncRNAs microarray to identify differentially expressed lncRNAs between primary melanoma and nevus.

2021-12-23 | GSE183878 | GEO

Pump-probe imaging differentiates melanoma from melanocytic nevi.

Project description: Not available

| S-EPMC3371363 | biostudies-literature